Protecting-group-free synthesis of a dual CCK1/CCK2 receptor antagonist.
نویسندگان
چکیده
In our pursuit of an efficient, protecting-group-free synthesis of the dual CCK1/CCK2 receptor antagonist 1, we have developed chemoselective conditions for sulfonamide formation reaction in pure water and a PhNMe(2) mediated carboxamide formation, both in the presence of a carboxylic acid. Practical synthesis of an unnatural, chiral β-aryl-α-amino acid is also described.
منابع مشابه
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 9 8 شماره
صفحات -
تاریخ انتشار 2011